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hrp0092fc13.6 | Adrenals and HP Axis | ESPE2019

Insights Into the Role of Cortisol in the Formation of the Clock/Bmal1 Complex and its Interaction with dsDNA, via Molecular Dynamics Simulations

Nicolaides Nicolas , Raftopoulou Sofia , Kino Tomoshige , Vlachakis Dimitrios , Chrousos George

Background: The circadian rhythm-generating peripheral Clock/Bmal1 heterodimer complex regulates the circadian activities of many biological systems, including the hypothalamic-pituitary-adrenal (HPA) axis, by trans-activating or trans-repressing downstream target genes.Objective and Hypotheses: To investigate the potential role of elevated cortisol in Clock/Bmal1 heterodimer complex-generated circadian biorhythms, both ...

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hrp0089lb-p4 | Late Breaking P1 | ESPE2018

An Updated Evolutionary Study in Glucocorticoid Receptors; Insights from a Comprehensive Phylogenetic, SNP’s and Mutation’s Analysis of the Nuclear Receptors Family: An Updated Evolutionary Study in Glucocorticoid Receptors; Insights from a Comprehensive Phylogenetic, SNP’s and Mutation’s Analysis of the Nuclear Receptors Family

Papageorgiou Louis , Papakonstantinou Eleni , Salis Constantinos , Raftopoulou Sofia , Mitsis Thanasis , Nicolaides Nicolas , Hagidimitriou Marianna , Eliopoulos Elias , Charmandari Evangelia , Chrousos George , Vlachakis Dimitrios

Background: Protein subfamilies within the Nuclear receptor (NR) family share common domain architecture. These closely related receptors and their cognate ligand compounds play a key role in homeostasis, reproduction, growth, and development. Despite their biological significance, their evolution and diversification remains to be elucidated. SNPs and mutations are characterized by the permanent alteration of the nucleotide sequence in the genome of an organism. These alterati...

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Insights Into the Role of Cortisol in the Formation of the Clock/Bmal1 Complex and its Interaction with dsDNA, via Molecular Dynamics Simulations

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